Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000408)
Formula
CYP2C19 ...
SVG example
Oxidative Deboronation
Reactant Bortezomib Product Bortezomib metabolite M1
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Oxidative Deboronation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000409 Bortezomib Bortezomib metabolite M2 Oxidation - Oxidation; Deboronation Bortezomib [1]
MR000411 Bortezomib Bortezomib metabolite M23 Unclear Bortezomib [1]
MR000412 Bortezomib Bortezomib metabolite M24 Unclear Bortezomib [1]
MR000410 Bortezomib Bortezomib metabolite M34 Unclear Bortezomib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000399 Bortezomib metabolite M1 Bortezomib metabolite M25 Oxidation - Hydoxylation Bortezomib [1]
MR000398 Bortezomib metabolite M1 Bortezomib metabolite M26 Oxidation - Hydoxylation Bortezomib [1]
MR000397 Bortezomib metabolite M1 Bortezomib metabolite M3 Hydrolysis - Hydrolysis Bortezomib [1]
MR000400 Bortezomib metabolite M1 Bortezomib metabolite M5 Oxidation - Hydoxylation Bortezomib [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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