Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000411)
Formula Reactant Bortezomib Product Bortezomib metabolite M23
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000408 Bortezomib Bortezomib metabolite M1 Oxidation - Oxidative Deboronation Bortezomib [1]
MR000409 Bortezomib Bortezomib metabolite M2 Oxidation - Oxidation; Deboronation Bortezomib [1]
MR000412 Bortezomib Bortezomib metabolite M24 Unclear Bortezomib [1]
MR000410 Bortezomib Bortezomib metabolite M34 Unclear Bortezomib [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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