Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000436)
Formula
CYP3A4 ...
SVG example
Reactant Brexpiprazole Product Brexpiprazole S-oxide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000438 Brexpiprazole Brexpiprazole metabolite M3 Unclear Brexpiprazole [1], [2]
MR000439 Brexpiprazole Brexpiprazole metabolite M5 Unclear Brexpiprazole [1], [2]
MR000441 Brexpiprazole Brexpiprazole metabolite M6 Unclear Brexpiprazole [1], [2]
MR000437 Brexpiprazole Brexpiprazole metabolite M7 Unclear Brexpiprazole [1], [2]
MR000440 Brexpiprazole Brexpiprazole metabolite M8 Unclear Brexpiprazole [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000434 Brexpiprazole S-oxide Brexpiprazole metabolite M4 Unclear Brexpiprazole [1], [2]
References
1 Brexpiprazole: first global approval. Drugs. 2015 Sep;75(14):1687-97.
2 Pharmacokinetics and metabolism of brexpiprazole, a novel serotonin-dopamine activity modulator and its main metabolite in rat, monkey and human. Xenobiotica. 2021 May;51(5):590-604. doi: 10.1080/00498254.2021.1890275.

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