Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008510)
Formula Reactant AP26113 Product AP26123
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Multi-steps Reaction - N-demethylation; cysteine conjugation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008513 AP26113 BGB486 Multi-steps Reaction - N-Dealkylation; loss of N-methyl piperazine ring AP26113 [1]
MR008512 AP26113 BGB570 Oxidation - N-Demethylation AP26113 [1]
MR008514 AP26113 BGB598 Oxidation - A-Oxidation AP26113 [1]
MR008511 AP26113 BGB600 Oxidation - A-Hydroxylation AP26113 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000442 Brigatinib AP26123 Oxidation - N-Demethylation; Cysteine Conjugation Brigatinib [2]
References
1 LC-ESI-MS/MS reveals the formation of reactive intermediates in brigatinib metabolism: elucidation of bioactivation pathways
2 Brigatinib: first global approval. Drugs. 2017 Jul;77(10):1131-1135.

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