General Information of This Metabolic Reaction (MR) (ID:
MR008510) |
Formula |
Reactant |
AP26113 |
Product |
AP26123 |
Reactant Info
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Product Info
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Metabolic Enzyme
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Cytochrome P450 3A4 (CYP3A4)
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DME Info
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Cytochrome P450 2C8 (CYP2C8)
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DME Info
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Metabolic Type
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Multi-steps Reaction
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N-demethylation; cysteine conjugation
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Other MR(s) Related to The Reactant of This MR |
Other MR(s) That Metabolize The Reactant of This MR
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Other MR(s) Related to The Product of This MR |
Other MR(s) That Produce The Product of This MR
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References |
1 |
LC-ESI-MS/MS reveals the formation of reactive intermediates in brigatinib metabolism: elucidation of bioactivation pathways
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2 |
Brigatinib: first global approval. Drugs. 2017 Jul;77(10):1131-1135.
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