Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000538)
Formula
CYP3A4 ...
SVG example
N-Oxidation
Reactant Cabozantinib Product EXEL-5162
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Oxidation - N-Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000536 Cabozantinib 4-Fluoroaniline Unclear Cabozantinib [1]
MR000537 Cabozantinib EXEL-1646 Conjugation - Monohydroxy Sulphation Cabozantinib [1]
MR000535 Cabozantinib EXEL-5366 Unclear Cabozantinib [1]
References
1 Clinical Pharmacokinetics and Pharmacodynamics of Cabozantinib Clin Pharmacokinet. 2017 May;56(5):477-491. doi: 10.1007/s40262-016-0461-9.

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