Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000643)
Formula
CYP1A2 ...
SVG example
7-Hydroxylation
Reactant Chlorpromazine hydrochloride Product Hydroxychlorpromazine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - 7-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000644 Chlorpromazine hydrochloride Chlorpromazine-N-oxide Unclear Chlorpromazine hydrochloride [1]
MR000642 Chlorpromazine hydrochloride Demonomethylchlorpromazine Unclear Chlorpromazine hydrochloride [1], [2]
MR000645 Chlorpromazine hydrochloride Opromazine Unclear Chlorpromazine hydrochloride [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011380 Chlorpromazine Hydroxychlorpromazine Oxidation - 7-hydroxylation Chlorpromazine [3]
MR002007 Perphenazine Hydroxychlorpromazine Oxidation - Hydroxylation Perphenazine [4]
References
1 Classics in Chemical Neuroscience: Chlorpromazine ACS Chem Neurosci. 2019 Jan 16;10(1):79-88. doi: 10.1021/acschemneuro.8b00258.
2 Determination of chlorpromazine and its metabolites in animal-derived foods using QuEChERS-based extraction, EMR-Lipid cleanup, and UHPLC-Q-Orbitrap MS analysis. Food Chem. 2023 Mar 1;403:134298. doi: 10.1016/j.foodchem.2022.134298.
3 DrugBank(Pharmacology-Metabolism):Chlorpromazine
4 American Society of Health System Pharmacists; AHFS Drug Information 2010. Bethesda, MD. (2010), p. 2511

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