Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002007)
Formula
SVG example
Hydroxylation
Reactant Perphenazine Product Hydroxychlorpromazine
Reactant Info Product Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002008 Perphenazine Mesoridazine Unclear Perphenazine [1]
MR002005 Perphenazine N-Dealkylated perphenazine Oxidation - N-Dealkylation Perphenazine [2]
MR002006 Perphenazine Perphenazine sulfoxide Oxidation - S-Oxidation Perphenazine [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011380 Chlorpromazine Hydroxychlorpromazine Oxidation - 7-hydroxylation Chlorpromazine [4]
MR000643 Chlorpromazine hydrochloride Hydroxychlorpromazine Oxidation - 7-Hydroxylation Chlorpromazine hydrochloride [5], [6]
References
1 American Society of Health System Pharmacists; AHFS Drug Information 2010. Bethesda, MD. (2010), p. 2511
2 Anti-Parkinson's disease drugs and pharmacogenetic considerations Expert Opin Drug Metab Toxicol. 2013 Jul;9(7):859-74. doi: 10.1517/17425255.2013.789018.
3 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.
4 DrugBank(Pharmacology-Metabolism):Chlorpromazine
5 Classics in Chemical Neuroscience: Chlorpromazine ACS Chem Neurosci. 2019 Jan 16;10(1):79-88. doi: 10.1021/acschemneuro.8b00258.
6 Determination of chlorpromazine and its metabolites in animal-derived foods using QuEChERS-based extraction, EMR-Lipid cleanup, and UHPLC-Q-Orbitrap MS analysis. Food Chem. 2023 Mar 1;403:134298. doi: 10.1016/j.foodchem.2022.134298.

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