Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000736)
Formula
CYP3A4 ...
SVG example
Hydroxylation
Reactant Darifenacin hydrobromide Product UK-148,993
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000737 Darifenacin hydrobromide Phenyl hydroxylate Oxidation - Hydroxylation Darifenacin hydrobromide [1]
MR000740 Darifenacin hydrobromide UK-222,247 Unclear Darifenacin hydrobromide [1]
MR000739 Darifenacin hydrobromide UK-73,689 Oxidation - N-Dealkylation Darifenacin hydrobromide [1]
MR000738 Darifenacin hydrobromide UK-88,862 Oxidation - N-Dealkylation Darifenacin hydrobromide [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000735 UK-148,993 UK-346,036 Oxidation - N-Dealkylation Darifenacin hydrobromide [1]
References
1 The clinical pharmacokinetics of darifenacin. Clin Pharmacokinet. 2006;45(4):325-50.

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