Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000740)
Formula
CYP3A4 ...
SVG example
Reactant Darifenacin hydrobromide Product UK-222,247
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000737 Darifenacin hydrobromide Phenyl hydroxylate Oxidation - Hydroxylation Darifenacin hydrobromide [1]
MR000736 Darifenacin hydrobromide UK-148,993 Oxidation - Hydroxylation Darifenacin hydrobromide [1]
MR000739 Darifenacin hydrobromide UK-73,689 Oxidation - N-Dealkylation Darifenacin hydrobromide [1]
MR000738 Darifenacin hydrobromide UK-88,862 Oxidation - N-Dealkylation Darifenacin hydrobromide [1]
References
1 The clinical pharmacokinetics of darifenacin. Clin Pharmacokinet. 2006;45(4):325-50.

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