Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000903)
Formula
CYP3A4 ...
SVG example
Hydroxylation
Reactant Efavirenz Product 8-hydroxy-efavirenz
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000905 Efavirenz Efavirenz metabolite M2 Conjugation - Conjugation Efavirenz [1]
MR000904 Efavirenz Efavirenz metabolite M5 Oxidation - Hydroxylation Efavirenz [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000899 8-hydroxy-efavirenz Efavirenz metabolite M1 Conjugation - Conjugation Efavirenz [1], [2]
MR000898 8-hydroxy-efavirenz Efavirenz metabolite M8 Oxidation - Hydroxylation Efavirenz [3], [4], [5]
References
1 Clinical pharmacokinetics and drug-drug interactions of Elbasvir/Grazoprevir. Eur J Drug Metab Pharmacokinet. 2018 Oct;43(5):509-531.
2 The Activity of Members of the UDP-Glucuronosyltransferase Subfamilies UGT1A and UGT2B is Impaired in Patients with Liver Cirrhosis. Clin Pharmacokinet. 2023 Jun 16. doi: 10.1007/s40262-023-01261-3.
3 Induction of CYP3A4 by efavirenz in primary human hepatocytes: comparison with rifampin and phenobarbital. J Clin Pharmacol. 2004 Nov;44(11):1273-81.
4 Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218.
5 Evaluation of CYP2B6 induction and prediction of clinical drug-drug interactions: considerations from the IQ consortium induction working group-an industry perspective. Drug Metab Dispos. 2016 Oct;44(10):1720-30.

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