Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000936)
Formula
UGT1A9 ...
SVG example
Glucuronidation
Reactant Ertugliflozin Product Ertugliflozin metabolite M4a
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000933 Ertugliflozin Ertugliflozin metabolite M1a Oxidation - Hydroxylation Ertugliflozin [1], [2]
MR000934 Ertugliflozin Ertugliflozin metabolite M1b Oxidation - Hydroxylation Ertugliflozin [1], [2]
MR000932 Ertugliflozin Ertugliflozin metabolite M2 Conjugation - Glucuronidation Ertugliflozin [1], [2]
MR000935 Ertugliflozin Ertugliflozin metabolite M3 Conjugation - Glucuronidation Ertugliflozin [1], [2]
MR000937 Ertugliflozin Ertugliflozin metabolite M4b Conjugation - Glucuronidation Ertugliflozin [2]
MR000938 Ertugliflozin Ertugliflozin metabolite M4c Conjugation - Glucuronidation Ertugliflozin [2]
References
1 In Vitro Characterization of Ertugliflozin Metabolism by UDP-Glucuronosyltransferase and Cytochrome P450 Enzymes Drug Metab Dispos. 2020 Dec;48(12):1350-1363. doi: 10.1124/dmd.120.000171.
2 Pharmacokinetics, metabolism, and excretion of the antidiabetic agent ertugliflozin (PF-04971729) in healthy male subjects Drug Metab Dispos. 2013 Feb;41(2):445-56. doi: 10.1124/dmd.112.049551.

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