Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001235)
Formula
SVG example
Deacetylation
Reactant Acethydrazide Product Hydrazine
Reactant Info Product Info
Metabolic Enzyme N-acetyltransferase 2 (NAT2) DME Info
Metabolic Type Oxidation - Deacetylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001232 Acetylisoniazid Acethydrazide Unclear Isoniazid [1]
MR001237 Hydrazine Acethydrazide Conjugation - Acetylation Isoniazid [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001234 Acethydrazide Diacetylhydrazine Conjugation - Acetylation Isoniazid [1]
MR001236 Acethydrazide Isoniazid reactive metabolite Unclear Isoniazid [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001240 Isoniazid Hydrazine Unclear Isoniazid [1], [2]
MR002164 Procarbazine Hydrazine Unclear Procarbazine [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001237 Hydrazine Acethydrazide Conjugation - Acetylation Isoniazid [1]
MR001238 Hydrazine Isoniazid reactive metabolite Unclear Isoniazid [1]
References
1 Exploration of inhibition potential of isoniazid and its metabolites towards CYP2E1 in human liver microsomes through LC-MS/MS analysis J Pharm Biomed Anal. 2021 Sep 5;203:114223. doi: 10.1016/j.jpba.2021.114223.
2 Quantitative Analysis of Isoniazid and Its Four Primary Metabolites in Plasma of Tuberculosis Patients Using LC-MS/MS. Molecules. 2022 Dec 6;27(23):8607. doi: 10.3390/molecules27238607.
3 DrugBank(Pharmacology-Metabolism)Procarbazine

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