Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002164)
Formula
SVG example
Reactant Procarbazine Product Hydrazine
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002165 Procarbazine Azoprocarbazine Unclear Procarbazine [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001240 Isoniazid Hydrazine Unclear Isoniazid [3], [4]
MR001235 Acethydrazide Hydrazine Oxidation - Deacetylation Isoniazid [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001237 Hydrazine Acethydrazide Conjugation - Acetylation Isoniazid [3]
MR001238 Hydrazine Isoniazid reactive metabolite Unclear Isoniazid [3]
References
1 Tumour cytochrome P450 and drug activation. Curr Pharm Des. 2002;8(15):1335-47.
2 Plasma kinetics of procarbazine and azo-procarbazine in humans Anticancer Drugs. 2006 Jan;17(1):75-80. doi: 10.1097/01.cad.0000181591.85476.aa.
3 Exploration of inhibition potential of isoniazid and its metabolites towards CYP2E1 in human liver microsomes through LC-MS/MS analysis J Pharm Biomed Anal. 2021 Sep 5;203:114223. doi: 10.1016/j.jpba.2021.114223.
4 Quantitative Analysis of Isoniazid and Its Four Primary Metabolites in Plasma of Tuberculosis Patients Using LC-MS/MS. Molecules. 2022 Dec 6;27(23):8607. doi: 10.3390/molecules27238607.

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