Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001238)
Formula Reactant Hydrazine Product Isoniazid reactive metabolite
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2E1 (CYP2E1) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001240 Isoniazid Hydrazine Unclear Isoniazid [1], [2]
MR002164 Procarbazine Hydrazine Unclear Procarbazine [3]
MR001235 Acethydrazide Hydrazine Oxidation - Deacetylation Isoniazid [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001237 Hydrazine Acethydrazide Conjugation - Acetylation Isoniazid [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001236 Acethydrazide Isoniazid reactive metabolite Unclear Isoniazid [1]
References
1 Exploration of inhibition potential of isoniazid and its metabolites towards CYP2E1 in human liver microsomes through LC-MS/MS analysis J Pharm Biomed Anal. 2021 Sep 5;203:114223. doi: 10.1016/j.jpba.2021.114223.
2 Quantitative Analysis of Isoniazid and Its Four Primary Metabolites in Plasma of Tuberculosis Patients Using LC-MS/MS. Molecules. 2022 Dec 6;27(23):8607. doi: 10.3390/molecules27238607.
3 DrugBank(Pharmacology-Metabolism)Procarbazine

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