Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009626)
Formula
CYP2C8 ...
SVG example
4-hydroxylation
Reactant Tretinoin Product 4-Hydroxyretinoic acid
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 3A7 (CYP3A7) DME Info
Cytochrome P450 2C18 (CYP2C18) DME Info
Lauric acid omega-hydroxylase (CYP4A11) DME Info
Cytochrome P450 1A1 (CYP1A1) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Metabolic Type Oxidation - 4-hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009631 Tretinoin 13-cis RA Other reaction - Isomerization Tretinoin [1], [2]
MR009636 Tretinoin 18-OH-RA Oxidation - Hydroxylation Tretinoin [3], [2], [1]
MR009637 Tretinoin 3,4-Didehydroretinoic acid Oxidation - Oxidation Tretinoin [4]
MR009629 Tretinoin 5,6-epoxy-RA Oxidation - Ring epoxidation Tretinoin [2], [2], [3]
MR009634 Tretinoin 9-cis RA Other reaction - Isomerization Tretinoin [1], [2]
MR009638 Tretinoin Retinotaurine Oxidation - Oxidation Tretinoin [4]
MR009639 Tretinoin Retinoyl beta-glucuronide Conjugation - Glucuronidation Tretinoin [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006380 NSC-122758 4-Hydroxyretinoic acid Oxidation - 4-hydroxylation NSC-122758 [3]
MR001254 All-trans-retinoic acid 4-hydroxyretinoic acid Oxidation - 4-Hydroxylation Isotretinoin [5]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009627 4-Hydroxyretinoic acid 4-Oxoretinoic acid Oxidation - Oxidation Tretinoin [3], [2]
MR001259 4-hydroxyretinoic acid 4-Oxoretinoic acid Oxidation - Oxidation Isotretinoin [5]
References
1 Human cytochrome P450s involved in the metabolism of 9-cis- and 13-cis-retinoic acids
2 Retinoic acid metabolism and mechanism of action: a review
3 Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8.
4 Clinical pharmacokinetics of tretinoin
5 DrugBank(Pharmacology-Metabolism)Isotretinoin

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