Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001351)
Formula Reactant Ketoconazole ketone hydroxyl intermediate Product M2 (Ketoconazole)
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - N-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001349 Ketoconazole ketone intermediate Ketoconazole ketone hydroxyl intermediate Other reaction - Hydration Ketoconazole [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001350 Ketoconazole ketone hydroxyl intermediate M5 (Ketoconazole) Oxidation - Oxidation Ketoconazole [1]
References
1 Revisiting the metabolism of ketoconazole using accurate mass Drug Metab Lett. 2009 Aug;3(3):191-8. doi: 10.2174/187231209789352085.

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