Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001470)
Formula
SVG example
Reactant Levobupivacaine Product N-desbutylbupivacaine
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001468 Levobupivacaine 3-hydroxy levobupivacaine Oxidation - N-Dealkylation Levobupivacaine [1]
MR001469 Levobupivacaine Desbutyl levobupivacaine Oxidation - Deamination Levobupivacaine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000481 Bupivacaine hydrochloride N-desbutylbupivacaine Unclear Bupivacaine hydrochloride [2]
MR008137 Mepivacaine 2',6'-pipecoloxylidide Oxidation - N-demethylation Mepivacaine [3]
References
1 Clinical profile of levobupivacaine in regional anesthesia: A systematic review. J Anaesthesiol Clin Pharmacol. 2013 Oct;29(4):530-9.
2 Structural elucidation of phase I and II metabolites of bupivacaine in horse urine and fungi of the Cunninghamella species using liquid chromatography/multi-stage mass spectrometry Rapid Commun Mass Spectrom. 2012 Jun 15;26(11):1338-46. doi: 10.1002/rcm.6225.
3 Clearance and metabolism of mepivacaine in the human neonate

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