Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001505)
Formula Reactant Levomilnacipran Product N-desethyl LVM
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 2J2 (CYP2J2) DME Info
Metabolic Type Oxidation - Desmethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001507 Levomilnacipran Levomilnacipran glucuronide Conjugation - Glucuronidation Levomilnacipran [1]
MR001506 Levomilnacipran p-hydroxy-levomilnacipran Oxidation - Hydroxylation Levomilnacipran [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001503 N-desethyl LVM Desethyl levomilnacipran glucuronide Conjugation - Glucuronidation Levomilnacipran [2]
References
1 LABEL:EVOMILNACIPRAN capsule, extended release
2 The role of levomilnacipran in the management of major depressive disorder: a comprehensive review. Curr Neuropharmacol. 2016;14(2):191-9.

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