Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001544)
Formula
ME1
SVG example
Reactant Malate Product Pyruvate
Reactant Info Product Info
Metabolic Enzyme NADP-dependent malic enzyme (ME1) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005857 Malate Oxaloacetate Oxidation - Oxidationn Malate [1]
MR005858 Malate Unclear Unclear Malate [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007375 BRN-4179169 Pyruvate Unclear BRN-4179169 [4]
MR006275 D-glucose Pyruvate Unclear D-glucose [5]
MR003906 E-920 Pyruvate Unclear E-920 [6]
MR004263 Methylglyoxal Pyruvate Unclear Methylglyoxal [7]
MR004433 Oxaloacetate Pyruvate Unclear Oxaloacetate [8]
MR007591 Phosphoenolpyruvate Pyruvate Unclear Phosphoenolpyruvate [9]
MR006379 Sialic acid Pyruvate Unclear Sialic acid [10]
MR003901 D-cysteine Pyruvate Unclear E-920 [6]
MR004262 D-lactaldehyde Pyruvate Unclear Methylglyoxal [7]
MR003899 Mercaptopyruvate Pyruvate Unclear E-920 [6]
MR007373 Mercaptopyruvate Pyruvate Unclear BRN-4179169 [4]
MR003693 PEP Pyruvate Unclear L-651582 [11]
MR003893 3-sulfino-pyruvate Pyruvate Unclear E-920 [6]
MR004208 63P PYR Unclear D-xylulose [12]
MR004180 Phosphoenolpyruvate Pyruvate Unclear Dihydroxyacetone [13]
MR004256 D-lactate Pyruvate Unclear Methylglyoxal [7]
MR002229 Selenocystein Pyruvate Oxidation - Degradation Selenium [14], [15], [16]
MR002233 Selenocysteine selenoxidel Pyruvate Oxidation - Degradation Selenium [14]
MR014120 PEP Pyruvate Unclear Lactose [17]
MR014124 PEP Pyruvate Unclear Lactose [17]
MR003945 PEP Pyruvate Unclear Lactose [17]
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Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004434 Pyruvate A-acetolactate Other reaction - #NAME? Oxaloacetate [8]
MR004436 Pyruvate Acetyl-P Unclear Oxaloacetate [8]
MR003694 Pyruvate Lactate Unclear L-651582 [11]
MR007374 Pyruvate Lactate Unclear BRN-4179169 [4]
MR004209 PYR Acetaldehyde Unclear D-xylulose [12]
MR004181 Pyruvate Alanine Unclear Dihydroxyacetone [13]
MR004257 Pyruvate L-lactate Unclear Methylglyoxal [7]
MR014121 Pyruvate Lactate Unclear Lactose [17]
MR014125 Pyruvate Lactate Unclear Lactose [17]
MR003946 Pyruvate Lactate Unclear Lactose [17]
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References
1 Malate and Aspartate Increase L-Arginine and Nitric Oxide and Attenuate Hypertension
2 Thermostable, ammonium-activated malic enzyme of Clostridium thermocellum. Biochim Biophys Acta. 1981 Aug 13;660(2):251-5.
3 The correlation between Clostridium-difficile infection and human gut concentrations of Bacteroidetes phylum and clostridial species. Eur J Clin Microbiol Infect Dis. 2014 Mar;33(3):377-83.
4 Non-invasive monitoring of L-2-oxothiazolidine-4-carboxylate metabolism in the rat brain by in vivo 13C magnetic resonance spectroscopy
5 DrugBank(Pharmacology-Metabolism):D-glucose
6 The mercaptopyruvate pathway in cysteine catabolism: a physiologic role and related disease of the multifunctional 3-mercaptopyruvate sulfurtransferase
7 Cells producing their own nemesis: understanding methylglyoxal metabolism
8 Mechanism of citrate metabolism by an oxaloacetate decarboxylase-deficient mutant of Lactococcus lactis IL1403
9 Pyruvate kinase M2: A simple molecule with complex functions
10 Crystal structures and kinetics of N-acetylneuraminate lyase from Fusobacterium nucleatum. Acta Crystallogr F Struct Biol Commun. 2018 Nov 1;74(Pt 11):725-732.
11 Metabolic Mechanisms and a Rational Combinational Application of Carboxyamidotriazole in Fighting Pancreatic Cancer Progression after Chemotherapy
12 Effects of increased transaldolase activity on D-xylulose and D-glucose metabolism in Saccharomyces cerevisiae cell extracts
13 Probing hepatic metabolism of [2-(13)C]dihydroxyacetone in vivo with (1)H-decoupled hyperpolarized (13)C-MR
14 Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase. Carcinogenesis. 1999 Sep;20(9):1657-66.
15 Effects of Selenium Enrichment on Dough Fermentation Characteristics of Baker's Yeast. Foods. 2023 Jun 11;12(12):2343. doi: 10.3390/foods12122343.
16 Multiomics understanding of improved quality in cherry radish (Raphanus sativus L. var. radculus pers) after foliar application of selenium nanomaterials. Sci Total Environ. 2022 Jun 10;824:153712. doi: 10.1016/j.scitotenv.2022.153712.
17 Lactose metabolism in Streptococcus lactis: studies with a mutant lacking glucokinase and mannose-phosphotransferase activities

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