| General Information of This Metabolic Reaction (MR) (ID:
MR001685) |
| Formula |
|
| Reactant |
Milnacipran |
Product |
N-Desethyl milnacipran |
|
Reactant Info
|
Product Info
|
|
Metabolic Enzyme
|
Cytochrome P450 2J2 (CYP2J2)
|
DME Info
|
|
Cytochrome P450 3A4 (CYP3A4)
|
DME Info
|
|
Cytochrome P450 2D6 (CYP2D6)
|
DME Info
|
|
Cytochrome P450 2C8 (CYP2C8)
|
DME Info
|
|
Mephenytoin 4-hydroxylase (CYP2C19)
|
DME Info
|
|
Metabolic Type
|
Oxidation
-
Desethylation
|
|
|
|
|
|
|
|
| Other MR(s) Related to The Reactant of This MR |
|
Other MR(s) That Metabolize The Reactant of This MR
|
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|
| References |
| 1 |
Excretion and metabolism of milnacipran in humans after oral administration of milnacipran hydrochloride Drug Metab Dispos. 2012 Sep;40(9):1723-35. doi: 10.1124/dmd.112.045120.
|
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