Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001839)
Formula
CYP3A4 ...
SVG example
Hydroxylation
Reactant Ondansetron Product 8-OH-ondansetron
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001840 Ondansetron 6-OH-ondansetron Oxidation - Hydroxylation Ondansetron [1]
MR001837 Ondansetron 7-hydroxyl-N-desmethyl-ondansetron Oxidation - N-Demethylation Ondansetron [1]
MR001836 Ondansetron 7-OH-ondansetron Oxidation - Hydroxylation Ondansetron [2], [1]
MR001841 Ondansetron 8-hydroxyl-N-desmethyl-ondansetron Oxidation - N-Demethylation Ondansetron [1]
MR001838 Ondansetron N-desmethyl-ondansetron-7-O-beta-D-glucuronide metabolite Conjugation - Glucuronidation Ondansetron [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001835 8-OH-ondansetron 8-hydroxyl-N-desmethyl-ondansetron metabolite Oxidation - N-Demethylation Ondansetron [1]
References
1 Identification of novel ondansetron metabolites using LC/MS(n) and NMR J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Sep 15;1095:138-141. doi: 10.1016/j.jchromb.2018.07.013.
2 Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218.

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