Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001842)
Formula
SVG example
Reactant Org-33062 Product 1-Pyrimidinylpiperazine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001845 Org-33062 2-OH-gepirone Unclear Org-33062 [1]
MR001843 Org-33062 3'-OH-gepirone Unclear Org-33062 [1]
MR001844 Org-33062 5-OH-gepirone Unclear Org-33062 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000523 Buspirone 1-Pyrimidinylpiperazine Oxidation - N-Dealkylation Buspirone [2], [3], [4]
MR012622 Gepirone 2-(1-Piperazinyl)pyrimidine Unclear - Unclear Gepirone [5]
MR013728 PF-00734200 PF-00734200 metabolite M3 Oxidation - N-dealkylation PF-00734200 [6]
MR008816 Tandospirone 1\(2\pyrimidinyl)\piperazine (1\PP) Oxidation - Oxidative cleavage Tandospirone [7], [8]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012623 2-(1-Piperazinyl)pyrimidine 2-(Piperazin-1-yl)pyrimidin-5-ol Unclear - Unclear Gepirone [9]
MR008817 1\(2\pyrimidinyl)\piperazine (1\PP) 5-OH-1-PP Unclear - Unclear Tandospirone [8]
References
1 Human cytochromes mediating gepirone biotransformation at low substrate concentrations. Biopharm Drug Dispos. 2003 Mar;24(2):87-94.
2 Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes. Drug Metab Dispos. 2005 Apr;33(4):500-7.
3 DrugBank(Pharmacology-Metabolism)Buspirone
4 Interaction of buspirone and its major metabolites with human organic cation transporters. Fundam Clin Pharmacol. 2023 Feb 26. doi: 10.1111/fcp.12883.
5 Gepirone and 1-(2-pyrimidinyl)-piperazine in vitro: human cytochromes mediating transformation and cytochrome inhibitory effects
6 Metabolism, excretion, and pharmacokinetics of ((3,3-difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone, a dipeptidyl peptidase inhibitor, in rat, dog and human
7 Simultaneous determination of tandospirone and its active metabolite, 1-[2-pyrimidyl]-piperazine in rat plasma by LC-MS/MS and its application to a pharmacokinetic study
8 Identification of CYP3A4 as the primary cytochrome P450 responsible for the metabolism of tandospirone by human liver microsomes
9 PubChem:Gepirone

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