Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001948)
Formula
CYP3A4 ...
SVG example
Hydroxylation; N-Demethylation
Reactant Pazopanib Product Pazopanib hydrochloride
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Hydroxylation; N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001949 Pazopanib Pazopanib metabolite M1 Oxidation - Hydroxylation Pazopanib [1]
MR001950 Pazopanib Pazopanib metabolite M2 Oxidation - Hydroxylation Pazopanib [1]
MR001951 Pazopanib Pazopanib metabolite M3 Oxidation - N-Demethylation Pazopanib [1]
References
1 Bioavailability, metabolism and disposition of oral pazopanib in patients with advanced cancer Xenobiotica. 2013 May;43(5):443-53. doi: 10.3109/00498254.2012.734642.

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