Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002008)
Formula
SVG example
Reactant Perphenazine Product Mesoridazine
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002007 Perphenazine Hydroxychlorpromazine Oxidation - Hydroxylation Perphenazine [1]
MR002005 Perphenazine N-Dealkylated perphenazine Oxidation - N-Dealkylation Perphenazine [2]
MR002006 Perphenazine Perphenazine sulfoxide Oxidation - S-Oxidation Perphenazine [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004957 Thioridazine Thioridazine 2-sulfoxide Oxidation - S-oxidation Thioridazine [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004958 Thioridazine 2-sulfoxide Sulforidazine Unclear Thioridazine [4]
References
1 American Society of Health System Pharmacists; AHFS Drug Information 2010. Bethesda, MD. (2010), p. 2511
2 Anti-Parkinson's disease drugs and pharmacogenetic considerations Expert Opin Drug Metab Toxicol. 2013 Jul;9(7):859-74. doi: 10.1517/17425255.2013.789018.
3 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.
4 Extraction of structure-activity relationship information from high-throughput screening data Curr Med Chem. 2009;16(31):4049-57. doi: 10.2174/092986709789378189.

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