Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002005)
Formula Reactant Perphenazine Product N-Dealkylated perphenazine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Oxidation - N-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002007 Perphenazine Hydroxychlorpromazine Oxidation - Hydroxylation Perphenazine [1]
MR002008 Perphenazine Mesoridazine Unclear Perphenazine [1]
MR002006 Perphenazine Perphenazine sulfoxide Oxidation - S-Oxidation Perphenazine [2]
References
1 American Society of Health System Pharmacists; AHFS Drug Information 2010. Bethesda, MD. (2010), p. 2511
2 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.