Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004957)
Formula
CYP2D6 ...
SVG example
S-oxidation
Reactant Thioridazine Product Thioridazine 2-sulfoxide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - S-oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004961 Thioridazine Hydroxy-Thioridazine Unclear Thioridazine [1]
MR004959 Thioridazine N-desmethylthioridazine Oxidation - N-dealkylation Thioridazine [2]
MR004960 Thioridazine Thioridazine 5-sulfoxide Oxidation - S-oxidation Thioridazine [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002008 Perphenazine Mesoridazine Unclear Perphenazine [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004958 Thioridazine 2-sulfoxide Sulforidazine Unclear Thioridazine [2]
References
1 Pharmacokinetics and metabolism of thioridazine during co-administration of tricyclic antidepressants
2 Extraction of structure-activity relationship information from high-throughput screening data Curr Med Chem. 2009;16(31):4049-57. doi: 10.2174/092986709789378189.
3 American Society of Health System Pharmacists; AHFS Drug Information 2010. Bethesda, MD. (2010), p. 2511

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