Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002024)
Formula
CYP2C19 ...
SVG example
Methylation
Reactant Phenobarbital Product Mephobarbital
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A7 (CYP3A7) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Cytochrome P450 2E1 (CYP2E1) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2C18 (CYP2C18) DME Info
Metabolic Type Conjugation - Methylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002023 Phenobarbital 4-hydroxyphenobarbital Oxidation - 4-Hydroxylation Phenobarbital [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005954 Mephobarbital 4-hydroxymephobarbital Unclear DEA-2250 [2]
MR005953 Mephobarbital Phenobarbital Unclear DEA-2250 [2]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Pharmacogenetic roles of CYP2C19 and CYP2B6 in the metabolism of R- and S-mephobarbital in humans. Pharmacogenetics. 2004 Aug;14(8):549-56.

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