Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002076)
Formula
CYP1A2 ...
SVG example
Hydroxylation
Reactant Pomalidomide Product 5-hydroxypomalidomide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002077 Pomalidomide 7-hydroxypomalidomide Oxidation - Hydroxylation Pomalidomide [1], [2], [3]
MR002078 Pomalidomide Pomalidomide metabolite M10 Unclear Pomalidomide [1]
MR002080 Pomalidomide Pomalidomide metabolite M18 Unclear Pomalidomide [1]
MR002079 Pomalidomide Pomalidomide metabolite M19 Oxidation - Hydroxylation Pomalidomide [1], [2]
MR002081 Pomalidomide Pomalidomide metabolite M2 Unclear Pomalidomide [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002075 5-hydroxypomalidomide 5-hydroxypomalidomide glucuronide Conjugation - Glucuronidation Pomalidomide [1], [2], [3]
References
1 Absorption, metabolism and excretion of [14C]pomalidomide in humans following oral administration Cancer Chemother Pharmacol. 2013 Feb;71(2):489-501. doi: 10.1007/s00280-012-2040-6.
2 Pomalidomide: evaluation of cytochrome P450 and transporter-mediated drug-drug interaction potential in vitro and in healthy subjects. J Clin Pharmacol. 2015 Feb;55(2):168-78.
3 Metabolic profiles of pomalidomide in human plasma simulated with pharmacokinetic data in control and humanized-liver mice Xenobiotica. 2017 Oct;47(10):844-848. doi: 10.1080/00498254.2016.1247218.

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