Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002079)
Formula
CYP1A2 ...
SVG example
Hydroxylation
Reactant Pomalidomide Product Pomalidomide metabolite M19
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002076 Pomalidomide 5-hydroxypomalidomide Oxidation - Hydroxylation Pomalidomide [1], [2], [3]
MR002077 Pomalidomide 7-hydroxypomalidomide Oxidation - Hydroxylation Pomalidomide [1], [2], [3]
MR002078 Pomalidomide Pomalidomide metabolite M10 Unclear Pomalidomide [1]
MR002080 Pomalidomide Pomalidomide metabolite M18 Unclear Pomalidomide [1]
MR002081 Pomalidomide Pomalidomide metabolite M2 Unclear Pomalidomide [1]
References
1 Absorption, metabolism and excretion of [14C]pomalidomide in humans following oral administration Cancer Chemother Pharmacol. 2013 Feb;71(2):489-501. doi: 10.1007/s00280-012-2040-6.
2 Pomalidomide: evaluation of cytochrome P450 and transporter-mediated drug-drug interaction potential in vitro and in healthy subjects. J Clin Pharmacol. 2015 Feb;55(2):168-78.
3 Metabolic profiles of pomalidomide in human plasma simulated with pharmacokinetic data in control and humanized-liver mice Xenobiotica. 2017 Oct;47(10):844-848. doi: 10.1080/00498254.2016.1247218.

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