Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002083)
Formula
CYP3A4 ...
SVG example
N-Demethylation
Reactant Ponatinib hydrochloride Product AP24567
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002084 Ponatinib hydrochloride AP24592 Hydrolysis - Amide Hydrolysis Ponatinib hydrochloride [1]
MR002085 Ponatinib hydrochloride AP24600 Hydrolysis - Amide Hydrolysis Ponatinib hydrochloride [1]
MR002086 Ponatinib hydrochloride Ponatinib metabolite M3 Oxidation - Oxidtive Deamination Ponatinib hydrochloride [2]
References
1 Absorption, metabolism, and excretion of [(14)C]ponatinib after a single oral dose in humans Cancer Chemother Pharmacol. 2017 Mar;79(3):507-518. doi: 10.1007/s00280-017-3240-x.
2 In vitro metabolites characterization of ponatinib in human liver microsomes using ultra-high performance liquid chromatography combined with Q-Exactive-Orbitrap tandem mass spectrometry Biomed Chromatogr. 2020 Jun;34(6):e4819. doi: 10.1002/bmc.4819.

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