Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002300)
Formula Reactant Thiophene-4,5-epoxide Product Suprofen metabolite M2
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002305 Suprofen Thiophene-4,5-epoxide Unclear Suprofen [1]
MR006192 Tienilic acid Thiophene-4,5-epoxide Oxidation - Epoxidation Tienilic acid [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002299 Thiophene-4,5-epoxide Suprofen metabolite M1 Intermediate Unclear Suprofen [1]
MR002301 Thiophene-4,5-epoxide Suprofen metabolite M3 Unclear Suprofen [1]
MR002302 Thiophene-4,5-epoxide Suprofen metabolite M4 Unclear Suprofen [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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