Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002305)
Formula Reactant Suprofen Product Thiophene-4,5-epoxide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002306 Suprofen 5-OH-suprofen Oxidation - Oxidation Suprofen [1]
MR002307 Suprofen Suprofen glucuronide Conjugation - Glucuronidation Suprofen [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006192 Tienilic acid Thiophene-4,5-epoxide Oxidation - Epoxidation Tienilic acid [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002299 Thiophene-4,5-epoxide Suprofen metabolite M1 Intermediate Unclear Suprofen [1]
MR002300 Thiophene-4,5-epoxide Suprofen metabolite M2 Unclear Suprofen [1]
MR002301 Thiophene-4,5-epoxide Suprofen metabolite M3 Unclear Suprofen [1]
MR002302 Thiophene-4,5-epoxide Suprofen metabolite M4 Unclear Suprofen [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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