Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002335)
Formula Reactant Tapentadol Product hydroxy tapentado
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002334 Tapentadol N-desmethyl tapentadol Unclear Tapentadol [1], [2]
MR002336 Tapentadol Tapentadol O-sulfate Conjugation - Conjugation Tapentadol [3], [1], [4]
MR002337 Tapentadol Tapentadol-O-glucuronide Conjugation - Conjugation Tapentadol [1], [5]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002333 hydroxy tapentado . Conjugation - Conjugation Tapentadol [2]
References
1 Investigations into the drug-drug interaction potential of tapentadol in human liver microsomes and fresh human hepatocytes. Drug Metab Lett. 2008 Jan;2(1):67-75.
2 LABEL:UCYNTA- tapentadol hydrochloride tablet, film coated
3 On the Molecular Basis Underlying the Metabolism of Tapentadol Through Sulfation Eur J Drug Metab Pharmacokinet. 2017 Oct;42(5):793-800. doi: 10.1007/s13318-016-0392-8.
4 A case report on fatal intoxication by tapentadol: Study of distribution and metabolism Forensic Sci Int. 2021 Jul;324:110825. doi: 10.1016/j.forsciint.2021.110825.
5 In vitro and in vivo characterization of tapentadol metabolites Methods Find Exp Clin Pharmacol. 2010 Jan-Feb;32(1):31-8. doi: 10.1358/mf.2010.32.1.1434165.

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