Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002336)
Formula
UGT1A9 ...
SVG example
Conjugation
Reactant Tapentadol Product Tapentadol O-sulfate
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
Metabolic Type Conjugation - Conjugation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002335 Tapentadol hydroxy tapentado Oxidation - Hydroxylation Tapentadol [1]
MR002334 Tapentadol N-desmethyl tapentadol Unclear Tapentadol [1], [2]
MR002337 Tapentadol Tapentadol-O-glucuronide Conjugation - Conjugation Tapentadol [1], [3]
References
1 Investigations into the drug-drug interaction potential of tapentadol in human liver microsomes and fresh human hepatocytes. Drug Metab Lett. 2008 Jan;2(1):67-75.
2 LABEL:UCYNTA- tapentadol hydrochloride tablet, film coated
3 In vitro and in vivo characterization of tapentadol metabolites Methods Find Exp Clin Pharmacol. 2010 Jan-Feb;32(1):31-8. doi: 10.1358/mf.2010.32.1.1434165.

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