Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002337)
Formula
SULT1A3 ...
SVG example
Conjugation
Reactant Tapentadol Product Tapentadol-O-glucuronide
Reactant Info Product Info
Metabolic Enzyme Sulfotransferase 1A3 (SULT1A3) DME Info
Sulfotransferase 1C4 (SULT1C4) DME Info
Sulfotransferase 1A1 (SULT1A1) DME Info
Metabolic Type Conjugation - Conjugation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002335 Tapentadol hydroxy tapentado Oxidation - Hydroxylation Tapentadol [1]
MR002334 Tapentadol N-desmethyl tapentadol Unclear Tapentadol [1], [2]
MR002336 Tapentadol Tapentadol O-sulfate Conjugation - Conjugation Tapentadol [3], [1], [4]
References
1 Investigations into the drug-drug interaction potential of tapentadol in human liver microsomes and fresh human hepatocytes. Drug Metab Lett. 2008 Jan;2(1):67-75.
2 LABEL:UCYNTA- tapentadol hydrochloride tablet, film coated
3 On the Molecular Basis Underlying the Metabolism of Tapentadol Through Sulfation Eur J Drug Metab Pharmacokinet. 2017 Oct;42(5):793-800. doi: 10.1007/s13318-016-0392-8.
4 A case report on fatal intoxication by tapentadol: Study of distribution and metabolism Forensic Sci Int. 2021 Jul;324:110825. doi: 10.1016/j.forsciint.2021.110825.

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