Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002400)
Formula
CYP1A2 ...
SVG example
Oxidation
Reactant Hydroxyterbinafine Product Carboxyterbinafine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002408 Terbinafine hydrochloride Hydroxyterbinafine Oxidation - Hydoxylation Terbinafine hydrochloride [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002399 Hydroxyterbinafine N-Desmethylhydroxyterbinafine Oxidation - N-Demethylation Terbinafine hydrochloride [1], [2]
References
1 Multiple cytochrome P-450s involved in the metabolism of terbinafine suggest a limited potential for drug-drug interactions. Drug Metab Dispos. 1999 Sep;27(9):1029-38.
2 A multi-residue chiral liquid chromatography coupled with tandem mass spectrometry method for analysis of antifungal agents and their metabolites in aqueous environmental matrices. Anal Methods. 2021 Jun 14;13(22):2466-2477. doi: 10.1039/d1ay00556a.

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