Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002408)
Formula
CYP1A2 ...
SVG example
Hydoxylation
Reactant Terbinafine hydrochloride Product Hydroxyterbinafine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - Hydoxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002410 Terbinafine hydrochloride 1-Naphthaldehyde Oxidation - Deamination Terbinafine hydrochloride [1]
MR002409 Terbinafine hydrochloride N-Desmethylterbinafine Oxidation - N-Demethylation Terbinafine hydrochloride [1]
MR002411 Terbinafine hydrochloride Terbinafine dihydrodiol derivative (1) Oxidation - Dihydroxylation Terbinafine hydrochloride [1]
MR002412 Terbinafine hydrochloride Terbinafine dihydrodiol derivative (2) Oxidation - Dihydroxylation Terbinafine hydrochloride [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002400 Hydroxyterbinafine Carboxyterbinafine Oxidation - Oxidation Terbinafine hydrochloride [1]
MR002399 Hydroxyterbinafine N-Desmethylhydroxyterbinafine Oxidation - N-Demethylation Terbinafine hydrochloride [1], [2]
References
1 Multiple cytochrome P-450s involved in the metabolism of terbinafine suggest a limited potential for drug-drug interactions. Drug Metab Dispos. 1999 Sep;27(9):1029-38.
2 A multi-residue chiral liquid chromatography coupled with tandem mass spectrometry method for analysis of antifungal agents and their metabolites in aqueous environmental matrices. Anal Methods. 2021 Jun 14;13(22):2466-2477. doi: 10.1039/d1ay00556a.

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