Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002407)
Formula Reactant Terbinafine dihydrodiol derivative (2) Product N-Desmethylterbinafine dihydrodiol derivative (2)
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002412 Terbinafine hydrochloride Terbinafine dihydrodiol derivative (2) Oxidation - Dihydroxylation Terbinafine hydrochloride [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002402 N-Desmethylterbinafine N-Desmethylterbinafine dihydrodiol derivative (2) Oxidation - Dihydroxylation Terbinafine hydrochloride [1]
References
1 Multiple cytochrome P-450s involved in the metabolism of terbinafine suggest a limited potential for drug-drug interactions. Drug Metab Dispos. 1999 Sep;27(9):1029-38.

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