Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002485)
Formula
ES
SVG example
Hydrolysis
Reactant Valbenazine Product [+]alpha-HTBZ
Reactant Info Product Info
Metabolic Enzyme Esterases (ES) DME Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002484 Valbenazine NBI-136110 Oxidation - Oxidation Valbenazine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009236 Ingrezza (+)-alpha-HTBZ Hydrolysis - Hydrolysis Ingrezza [1]
MR004908 Tetrabenazine Alpha-dihydrotetrabenazine Unclear Tetrabenazine [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004909 Alpha-dihydrotetrabenazine 9-desmethyl-alpha-DHTBZ Unclear Tetrabenazine [2]
References
1 Pharmacologic Characterization of Valbenazine (NBI-98854) and Its Metabolites J Pharmacol Exp Ther. 2017 Jun;361(3):454-461. doi: 10.1124/jpet.116.239160.
2 DrugBank(Pharmacology-Metabolism):Tetrabenazine

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