Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004909)
Formula Reactant Alpha-dihydrotetrabenazine Product 9-desmethyl-alpha-DHTBZ
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009236 Ingrezza (+)-alpha-HTBZ Hydrolysis - Hydrolysis Ingrezza [1]
MR004908 Tetrabenazine Alpha-dihydrotetrabenazine Unclear Tetrabenazine [2]
MR002485 Valbenazine [+]alpha-HTBZ Hydrolysis - Hydrolysis Valbenazine [1], [3]
References
1 Pharmacologic Characterization of Valbenazine (NBI-98854) and Its Metabolites J Pharmacol Exp Ther. 2017 Jun;361(3):454-461. doi: 10.1124/jpet.116.239160.
2 DrugBank(Pharmacology-Metabolism):Tetrabenazine
3 Pharmacokinetic and Pharmacologic Characterization of the Dihydrotetrabenazine Isomers of Deutetrabenazine and Valbenazine. Clin Pharmacol Drug Dev. 2023 Apr;12(4):447-456. doi: 10.1002/cpdd.1205.

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