Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004908)
Formula
SVG example
Reactant Tetrabenazine Product Alpha-dihydrotetrabenazine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004910 Tetrabenazine B-dihydrotetrabenazine Unclear Tetrabenazine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009236 Ingrezza (+)-alpha-HTBZ Hydrolysis - Hydrolysis Ingrezza [2]
MR002485 Valbenazine [+]alpha-HTBZ Hydrolysis - Hydrolysis Valbenazine [2], [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004909 Alpha-dihydrotetrabenazine 9-desmethyl-alpha-DHTBZ Unclear Tetrabenazine [1]
References
1 DrugBank(Pharmacology-Metabolism):Tetrabenazine
2 Pharmacologic Characterization of Valbenazine (NBI-98854) and Its Metabolites J Pharmacol Exp Ther. 2017 Jun;361(3):454-461. doi: 10.1124/jpet.116.239160.
3 Pharmacokinetic and Pharmacologic Characterization of the Dihydrotetrabenazine Isomers of Deutetrabenazine and Valbenazine. Clin Pharmacol Drug Dev. 2023 Apr;12(4):447-456. doi: 10.1002/cpdd.1205.

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