Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002494)
Formula
CYP2B6 ...
SVG example
5-Hydroxylation
Reactant Valproic acid Product 5-hydroxyvalproic acid
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2B6 (CYP2B6) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 2A6 (CYP2A6) DME Info
Metabolic Type Oxidation - 5-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002499 Valproic acid (3E)-2-Propylpent-3-enoic acid Unclear Valproic acid [1]
MR002498 Valproic acid (3Z)-2-Propylpent-3-enoic acid Oxidation - Dehydrogenation Valproic acid [1]
MR002496 Valproic acid 2-ene-Valproic acid Oxidation - Dehydrogenation Valproic acid [1]
MR002495 Valproic acid 3-hydroxyvalproic acid Unclear Valproic acid [1]
MR002493 Valproic acid 4-ene-Valproic acid Oxidation - 3-Hydroxylation Valproic acid [1]
MR002492 Valproic acid 4-hydroxyvalproic acid Oxidation - 4-Hydroxylation Valproic acid [1]
MR002497 Valproic acid Valproic acid beta-O-glucuronide metabolite Oxidation - Dehydrogenation Valproic acid [1]
MR002500 Valproic acid Valproic acid CoA Unclear Valproic acid [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010556 Divalproex sodium 5-OH-VPA Unclear - Unclear Divalproex sodium [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002489 5-hydroxyvalproic acid 2-Propylglutaric acid Oxidation - Dehydrogenation Valproic acid [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 PharmGKB: the Pharmacogenomics Knowledge Base Methods Mol Biol. 2013;1015:311-20. doi: 10.1007/978-1-62703-435-7_20.

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