Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002588)
Formula
CYP3A4 ...
SVG example
10,11-Epoxidation
Reactant Carbamazepine Product 10,11-Epoxycarbamazepine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Oxidation - 10,11-Epoxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002589 Carbamazepine 3-hydroxycarbamazepine Oxidation - 3-Hydroxylation Carbamazepine [1]
MR002587 Carbamazepine Carbamazepine 2,3-epoxide Unclear Carbamazepine [1]
MR002590 Carbamazepine Carbamazepine N-glucuronide Conjugation - N-Glucuronidation Carbamazepine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002584 10,11-Epoxycarbamazepine 10,11-Dihydroxycarbamazepine Unclear Carbamazepine [1]
MR002585 10,11-Epoxycarbamazepine 9-hydroxymethyl-10-carbamaoyl acridan Unclear Carbamazepine [2]
References
1 Carbamazepine and its metabolites in human perfused placenta and in maternal and cord blood Epilepsia. 1995 Mar;36(3):241-8. doi: 10.1111/j.1528-1157.1995.tb00991.x.
2 PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA165817070)

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