General Information of This Metabolic Reaction (MR) (ID: MR002720)
Formula
UGT1A1 ...
SVG example
O-Glucuronidation
Reactant Ethinyl estradiol Product N-desmethylzopiclone
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
UDP-glucuronosyltransferase 1A4 (UGT1A4) DME Info
Metabolic Type Conjugation - O-Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002725 Ethinyl estradiol 16alpha-hydroxyethinylestradiol Oxidation - 16-Hydroxylation Ethinyl estradiol [1]
MR002721 Ethinyl estradiol 2-hydroxyethinylestradiol Oxidation - 2-Hydroxylation Ethinyl estradiol [1]
MR002722 Ethinyl estradiol 4-hydroxyethinylestradiol Oxidation - 4-Hydroxylation Ethinyl estradiol [1]
MR002723 Ethinyl estradiol 6-hydroxyethinylestradiol Oxidation - 6-Hydroxylation Ethinyl estradiol [1]
MR002724 Ethinyl estradiol 7-hydroxyethinylestradiol Oxidation - 7-Hydroxylation Ethinyl estradiol [1]
MR002728 Ethinyl estradiol Ethinylestradiol-17-sulfate Conjugation - Sulfation Ethinyl estradiol [2]
MR002727 Ethinyl estradiol Ethinylestradiol-3,17-sulfate Conjugation - Sulfation Ethinyl estradiol [2]
MR002726 Ethinyl estradiol Ethinylestradiol-3-sulfate Conjugation - Sulfation Ethinyl estradiol [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002713 Eszopiclone N-desmethylzopiclone Oxidation - N-Demethylation Eszopiclone [3]
MR009651 Zopiclone N-desmethylzopiclone Oxidation - N-demethylation Zopiclone [4], [5]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002710 N-desmethylzopiclone 2-amino-5-chloropyridine Unclear Eszopiclone [3]
References
1 Sulfotransferase 1E1 is a low km isoform mediating the 3-O-sulfation of ethinyl estradiol Drug Metab Dispos. 2004 Nov;32(11):1299-303. doi: 10.1124/dmd.32.11..
2 The pharmacokinetics and metabolism of ethinyl estradiol and its three sulfates in the baboon Am J Obstet Gynecol. 1983 May 1;146(1):80-7. doi: 10.1016/0002-9378(83)90931-6.
3 Development of a novel tandem mass spectrometry method for the quantification of eszopiclone without interference from 2-amino-5-chloropyridine and application in a pharmacokinetic study of rat J Pharm Biomed Anal. 2020 Sep 5;188:113363. doi: 10.1016/j.jpba.2020.113363.
4 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
5 Distribution of zopiclone and main metabolites in hair following a single dose

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