Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002713)
Formula
CYP3A4 ...
SVG example
N-Demethylation
Reactant Eszopiclone Product N-desmethylzopiclone
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002712 Eszopiclone 2-amino-5-chloropyridine Unclear Eszopiclone [1]
MR002714 Eszopiclone Carbon dioxide Oxidation - Oxidative Decarboxylation Eszopiclone [2]
MR002711 Eszopiclone Zopiclone N-oxide Oxidation - N-Oxidation Eszopiclone [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002720 Ethinyl estradiol N-desmethylzopiclone Conjugation - O-Glucuronidation Ethinyl estradiol [3]
MR009651 Zopiclone N-desmethylzopiclone Oxidation - N-demethylation Zopiclone [4], [5]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002710 N-desmethylzopiclone 2-amino-5-chloropyridine Unclear Eszopiclone [1]
References
1 Development of a novel tandem mass spectrometry method for the quantification of eszopiclone without interference from 2-amino-5-chloropyridine and application in a pharmacokinetic study of rat J Pharm Biomed Anal. 2020 Sep 5;188:113363. doi: 10.1016/j.jpba.2020.113363.
2 IMOVANE (Zopiclone) Product Monograph
3 Human bilirubin UDP-glucuronosyltransferase catalyzes the glucuronidation of ethinylestradiol Mol Pharmacol. 1993 Apr;43(4):649-54.
4 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
5 Distribution of zopiclone and main metabolites in hair following a single dose

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