Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009651)
Formula
CYP3A4 ...
SVG example
N-demethylation
Reactant Zopiclone Product N-desmethylzopiclone
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009650 Zopiclone Carbon dioxide Oxidation - Oxidative decarboxylation Zopiclone [1]
MR009649 Zopiclone Zopiclone N-oxide Oxidation - N-oxidation Zopiclone [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002713 Eszopiclone N-desmethylzopiclone Oxidation - N-Demethylation Eszopiclone [3]
MR002720 Ethinyl estradiol N-desmethylzopiclone Conjugation - O-Glucuronidation Ethinyl estradiol [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002710 N-desmethylzopiclone 2-amino-5-chloropyridine Unclear Eszopiclone [3]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Distribution of zopiclone and main metabolites in hair following a single dose
3 Development of a novel tandem mass spectrometry method for the quantification of eszopiclone without interference from 2-amino-5-chloropyridine and application in a pharmacokinetic study of rat J Pharm Biomed Anal. 2020 Sep 5;188:113363. doi: 10.1016/j.jpba.2020.113363.
4 Human bilirubin UDP-glucuronosyltransferase catalyzes the glucuronidation of ethinylestradiol Mol Pharmacol. 1993 Apr;43(4):649-54.

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