Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002836)
Formula
CYP3A4 ...
SVG example
N-Oxidation
Reactant Clozapine Product Clozapine N-oxide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Dimethylaniline oxidase 3 (FMO3) DME Info
Metabolic Type Oxidation - N-Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002837 Clozapine Clozapine glucuronide Conjugation - Glucuronidation Clozapine [1]
MR002835 Clozapine N-desmethylclozapine Oxidation - N-Demethylation Clozapine [2]
References
1 DrugBank(Pharmacology-Metabolism)Clozapine
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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