Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002835)
Formula
CYP3A4 ...
SVG example
N-Demethylation
Reactant Clozapine Product N-desmethylclozapine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002837 Clozapine Clozapine glucuronide Conjugation - Glucuronidation Clozapine [1]
MR002836 Clozapine Clozapine N-oxide Oxidation - N-Oxidation Clozapine [2]
References
1 DrugBank(Pharmacology-Metabolism)Clozapine
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.