Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR002864)
Formula	CYP3A4 ... Hydroxylation
	Reactant	Palonosetron hydrochloride		Product	Palonosetron metabolite M4
	Reactant	Reactant Info		Product	Product Info
Metabolic Enzyme	Cytochrome P450 3A4 (CYP3A4)					DME Info
	Cytochrome P450 3A5 (CYP3A5)					DME Info
	Cytochrome P450 2D6 (CYP2D6)					DME Info
Metabolic Type	Oxidation - Hydroxylation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR002866	Palonosetron hydrochloride	Palonosetron metabolite M6	Unclear	Palonosetron hydrochloride	[1]
MR002865	Palonosetron hydrochloride	Palonosetron metabolite M9	Oxidation - N-Oxidation	Palonosetron hydrochloride	[1]

References
1	Pharmacokinetics, metabolism and excretion of intravenous [l4C]-palonosetron in healthy human volunteers Biopharm Drug Dispos. 2004 Nov;25(8):329-37. doi: 10.1002/bdd.410.

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