Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002865)
Formula
CYP3A4 ...
SVG example
N-Oxidation
Reactant Palonosetron hydrochloride Product Palonosetron metabolite M9
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - N-Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002864 Palonosetron hydrochloride Palonosetron metabolite M4 Oxidation - Hydroxylation Palonosetron hydrochloride [1]
MR002866 Palonosetron hydrochloride Palonosetron metabolite M6 Unclear Palonosetron hydrochloride [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002867 Palonosetron metabolite M9 Palonosetron metabolite M5 Unclear Palonosetron hydrochloride [1]
References
1 Pharmacokinetics, metabolism and excretion of intravenous [l4C]-palonosetron in healthy human volunteers Biopharm Drug Dispos. 2004 Nov;25(8):329-37. doi: 10.1002/bdd.410.

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